⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748761 | 0.84 | MAOA (0.32) | — | |
| Hydrochloric Acid SCHEMBL4521946 | 0.83 | MAOA (0.31) | — | |
| SCHEMBL3873900 | 0.82 | SIRT1 (0.40) | — | |
| SCHEMBL4503987 | 0.80 | F11 (0.40) | — | |
| SCHEMBL6962527 | 0.79 | ACE (0.40) | — | |
| SCHEMBL4514757 | 0.79 | OPRK1 (0.32) | — | |
| SCHEMBL6962545 | 0.79 | MEN1 (0.41) | — | |
| SCHEMBL6967292 | 0.78 | KEAP1 (0.38) | — | |
| Hydrochloric Acid SCHEMBL4504167 | 0.78 | OPRK1 (0.32) | — | |
| SCHEMBL8473067 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009135925-A1 | SUBSTITUTED N-IMIDAZO[2,1-B]THIAZOLE-5-SULFONAMIDE DERIVATIVES AS 5-HT6 LIGANDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-11-12 | — | — | WO | claimed |
| EP-2116547-A1 | Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-11-11 | — | — | EP | claimed |
| EP-2116547-A1 | Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-11-11 | — | — | EP | disclosed |