Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 2/20 | 0.56 |
| ▸ | P2RX1 | P51575 | 8/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.52 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.52 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812557 | 0.89 | MAPT (0.57) | FADS1P2RX1P2RX4P2RX7MAPT | |
| SCHEMBL13812570 | 0.79 | TMPRSS4 (0.69) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13812620 | 0.79 | FADS1 (0.65) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13812577 | 0.79 | P2RX1 (0.55) | FADS1P2RX1P2RX4P2RX7MAPT | |
| SCHEMBL13812556 | 0.78 | P2RX1 (0.60) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13812558 | 0.77 | P2RX1 (0.59) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13812621 | 0.77 | P2RX1 (0.67) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13189709 | 0.77 | FADS1 (0.82) | FADS1P2RX1P2RX4P2RX7MAPT | |
| SCHEMBL13812580 | 0.77 | TMPRSS4 (0.69) | FADS1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL13189704 | 0.76 | P2RX1 (0.67) | FADS1P2RX1P2RX4P2RX7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| EP-1542699-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS EMPLOYING SAME | MYRIAD GENETICS INC (US) | 2009-03-25 | — | — | EP | disclosed |
| US-20050187300-A1 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INCORPORATED (US) | 2005-08-25 | — | — | US | disclosed |
| EP-1542699-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS EMPLOYING SAME | MYRIAD GENETICS, INC. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004006858-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS EMPLOYING SAME | MYRIAD GENETICS, INC (US) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187300-A1 | Compounds, compositions, and methods employing same | HMGCR, APOB, PCSK9 | FADS1 282/4885P2RX1 3039/4885P2RX4 3360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.