Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL833414 | 0.84 | AOC3 (0.64) | AOC3CA2ALDH1A1CARM1PRMT6 | |
| SCHEMBL1794281 | 0.84 | AOC3 (0.64) | AOC3CA2ALDH1A1CARM1PRMT6 | |
| SCHEMBL4622916 | 0.83 | AOC3 (0.48) | AOC3AKR1B1NPC1RAB9ACA12 | |
| Hydrochloric Acid SCHEMBL11779718 | 0.82 | AOC3 (0.61) | AOC3LMNACA2ALDH1A1CARM1 | |
| Acetic Acid SCHEMBL27673324 | 0.77 | CARM1 (0.55) | AOC3NPC1RAB9ACA12CA9 | |
| SCHEMBL258776 | 0.76 | AOC3 (0.54) | AOC3AKR1B1NPC1RAB9ACA12 | |
| SCHEMBL27718040 | 0.76 | AOC3 (0.54) | AOC3NPC1RAB9ACA12CA9 | |
| Phenylacetic Acid SCHEMBL28668840 | 0.76 | AKR1B1 (0.81) | AKR1B1LMNACA2TSHRHTT | |
| SCHEMBL4210846 | 0.75 | LMNA (0.53) | AOC3NPC1RAB9AKDM4ELMNA | |
| SCHEMBL17454767 | 0.74 | MAOB (0.60) | AOC3NPC1RAB9AKDM4ECA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504521-B2 | Methods for the preparation of pyrrolotriazine compounds | BRISTOL-MYERS SQUIBB CO. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20060030708-A1 | Methods for the preparation of pyrrolotriazine compounds | BRISTOL-MYERS SQUIBB COMPANY | 2006-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030708-A1 | Methods for the preparation of pyrrolotriazine compounds | SDHB, SDHA, DHPS | AOC3 548/4885AKR1B1 1398/4885NPC1 2382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.