Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778124 | 0.81 | CA1 (0.47) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL22867349 | 0.79 | CA1 (0.46) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL6559198 | 0.79 | PTGES2 (0.53) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL2778205 | 0.79 | ACLY (0.49) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL31296510 | 0.79 | ACLY (0.49) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL31727449 | 0.77 | CA1 (0.47) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL3782276 | 0.77 | CA1 (0.47) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL14925398 | 0.76 | PDIA6 (0.47) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL20744421 | 0.76 | PTGES2 (0.50) | CA2CA1CA9CA12RAD51 | |
| SCHEMBL2775587 | 0.76 | TRPV4 (0.46) | CA2CA1CA9CA12RAD51 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1331221-B1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | KISSEI PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | claimed |
| CN-100439329-C | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing them and intermediates for their preparation | KISSEI PHARMACEUTICAL (JP) | 2008-12-03 | — | — | CN | claimed |
| US-7217832-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-15 | — | — | US | claimed |
| US-20060205812-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. | 2006-09-14 | — | — | US | claimed |
| US-20050014787-A1 | 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-01-20 | — | — | US | claimed |
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | claimed |
| CN-1468215-A | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | ����ҩƷ��ҵ��ʽ���� | 2004-01-14 | — | — | CN | claimed |
| EP-1331221-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-07-30 | — | — | EP | claimed |
| US-7589126-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-15 | — | — | US | disclosed |
| US-7563822-B2 | Agents for the prevention or treatment of renal diseases | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |
| EP-1331221-B1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | KISSEI PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | disclosed |
| CN-100439329-C | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing them and intermediates for their preparation | KISSEI PHARMACEUTICAL (JP) | 2008-12-03 | — | — | CN | disclosed |
| CN-100341496-C | Agent for preventing or treating kidney disease | KISSEI PHARMACEUTICAL (JP) | 2007-10-10 | — | — | CN | disclosed |
| US-7217832-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-15 | — | — | US | disclosed |
| US-20050014787-A1 | 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-01-20 | — | — | US | disclosed |
| US-20040242455-A1 | 5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide derivative, medical composition containing the same, pharmaceutical use thereof and intermediate therefor | KISSEI PAHRMACEUTICAL CO., LTD. (JP) | 2004-12-02 | — | — | US | disclosed |
| EP-1443041-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICINAL USE THEREOF AND INTERMEDIATES IN THE PRODUCTION THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-08-04 | — | — | EP | disclosed |
| EP-1415983-A1 | 5-AMIDINO-N-(2-AMINOPHENETHYL)-HYDROXYBENZENESULFONAMIDE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND INTERMEDIATE THEREFOR | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-05-06 | — | — | EP | disclosed |
| CN-1468215-A | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | ����ҩƷ��ҵ��ʽ���� | 2004-01-14 | — | — | CN | disclosed |
| EP-1331221-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205812-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | F12, F2, F5 | CA2 1040/4885CA1 3337/4885CA9 883/4885 |
| US-20050014787-A1 | 5-amidino-2-hydroxybenzenesulfonamide derivatives medicinal compoistions containing the same medicinal use thereof and intermediates in the production thereof | F2, HYPK, F10 | CA2 1021/4885CA1 288/4885CA9 383/4885 |
| US-20040242455-A1 | 5-amidino-n-(2-aminophenethyl)-n-hydroxy-benzenesulffonamide derivative, medical composition containing the same, pharmaceutical use thereof and intermediate therefor | F11, F2, F7 | CA2 1903/4885CA1 3513/4885CA9 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.