Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.67 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.66 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.66 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.66 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.66 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA7 | P43166 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.56 |
| ▸ | BID | P55957 | 7/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.56 |
| ▸ | BAK1 | Q16611 | 6/20 | 0.56 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.56 |
| ▸ | EP300 | Q09472 | 2/20 | 0.56 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.56 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9308264 | 0.83 | CA12 (0.67) | AKR1B1CA12CA1CA2CA7 | |
| SCHEMBL11571511 | 0.82 | CA12 (0.64) | AKR1B1CA12CA1CA2CA7 | |
| SCHEMBL31086255 | 0.82 | AKR1B1 (0.69) | AKR1B1DUSP3PTPN5PTPN11CTDSP1 | |
| SCHEMBL29919590 | 0.82 | BID (0.67) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3954149 | 0.82 | BID (0.67) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10886691 | 0.82 | AKR1B1 (0.69) | AKR1B1DUSP3PTPN5PTPN11CTDSP1 | |
| SCHEMBL16870672 | 0.81 | BID (0.61) | CA12CA1CA2CA7CA9 | |
| SCHEMBL72309 | 0.81 | AKR1B1 (1.00) | AKR1B1DUSP3PTPN5PTPN11CTDSP1 | |
| SCHEMBL30449014 | 0.81 | AKR1B1 (1.00) | AKR1B1DUSP3PTPN5PTPN11CTDSP1 | |
| SCHEMBL3875526 | 0.80 | BID (0.53) | DUSP3PTPN5PTPN11CTDSP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160331660-A1 | USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT | L'OREAL (FR) | 2016-11-17 | — | — | US | disclosed |
| WO-2009145718-A1 | ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |
| US-7511044-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2009-03-31 | — | — | US | disclosed |
| EP-2025666-A2 | Thiolalkyl benzoic acid derivatives | MGI GP, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-2025666-A2 | Thiolalkyl benzoic acid derivatives | MGI GP, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1406867-B1 | THIOLALKYL BENZOIC ACID DERIVATIVES | GUILFORD PHARM INC (US) | 2008-12-31 | — | — | EP | disclosed |
| EP-1406867-B1 | THIOLALKYL BENZOIC ACID DERIVATIVES | GUILFORD PHARM INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-7138543-B2 | Thiolalkyl benzoic acid derivatives | GUILFORD PHARMACEUTICALS INC. (US) | 2006-11-21 | — | — | US | disclosed |
| EP-1720868-A1 | PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN | AMGEN INC. (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005077944-A1 | PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN | AMGEN INC. (US) | 2005-08-25 | — | — | WO | disclosed |
| US-20040198824-A1 | Thioalkyl benzoic acid derivatives | GUILFORD PHARMACEUTICALS INC. | 2004-10-07 | — | — | US | disclosed |
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | GUILFORD PHARMACEUTICALS INC. | 2004-09-23 | — | — | US | disclosed |
| WO-2004078180-A2 | NAALADASE INHIBITORS FOR TREATING OPIOID TOLERANCE | GUILFORD PHARMACEUTICALS INC. (US) | 2004-09-16 | — | — | WO | disclosed |
| US-6740777-B2 | MERCAPTOALKYL BENZOIC ACID DERIVATIVE ARE USEFUL FOR INHIBITING NAALADASE (ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE/N-/) ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. | 2004-05-25 | — | — | US | disclosed |
| EP-1406867-A2 | THIOLALKYL BENZOIC ACID DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030100607-A1 | Mercaptoalkyl benzoic acid derivative are useful for inhibiting NAALADase (acetylated alpha-linked acidic dipeptidase/N-/) enzyme activity | EISAI INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2002096866-A2 | THIOLALKYL BENZOIC ACID DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| WO-1994027969-A1 | ISOQUINOLINETRIONE DERIVATIVES AS HERBICIDES | ZENECA LIMITED (GB) | 1994-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160331660-A1 | USE OF SALICYLIC ACID DERIVATIVES AS PRODESQUAMATING ACTIVE AGENT | HRH1, SUCNR1, PTGS1 | AKR1B1 572/4885DUSP3 2556/4885PTPN5 3786/4885 |
| US-20040198824-A1 | Thioalkyl benzoic acid derivatives | ALDH1A2, ALDH7A1, NAALAD2 | AKR1B1 783/4885DUSP3 4303/4885PTPN5 3780/4885 |
| US-20030100607-A1 | Mercaptoalkyl benzoic acid derivative are useful for inhibiting NAALADase (acetylated alpha-linked acidic dipeptidase/N-/) enzyme activity | NAALAD2, DNPEP, ALDH7A1 | AKR1B1 1284/4885DUSP3 3849/4885PTPN5 3844/4885 |
| US-20040186081-A1 | Naaladase inhibitors for treating opioid tolerance | OPRD1, OPRK1, OPRM1 | AKR1B1 338/4885DUSP3 352/4885PTPN5 1090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.