Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.31 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride Ion SCHEMBL7641950 | 0.79 | KDM4E (0.38) | CYP1A2KDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL7635462 | 0.75 | CHRNB2 (0.32) | — | |
| Hydrochloric Acid SCHEMBL3119117 | 0.73 | MAPT (0.30) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL438367 | 0.72 | HTR2C (0.34) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6895703 | 0.72 | HTR1A (0.39) | CYP1A2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL13750553 | 0.72 | CYP1A2 (0.40) | CYP1A2KDM4EALDH1A1LMNAGAA | |
| Hydrochloric Acid SCHEMBL5953029 | 0.70 | BRD4 (0.32) | — | |
| Hydrochloric Acid SCHEMBL3679764 | 0.70 | ALDH1A1 (0.33) | ALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL5951783 | 0.69 | HTR7 (0.35) | ALDH1A1CYP2A6 | |
| Hydrochloric Acid SCHEMBL4475246 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567560-B1 | ORGANOMETALLIC TRANSITION METAL COMPOUND, BISCYCLOPENTADIENYL LIGAND SYSTEM, CATALYST SYSTEM AND PROCESS FOR PREPARING POLYOLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |
| US-7405261-B2 | Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and process for preparing polyolefins | BASELL POLYOLEFINE GMBH (DE) | 2008-07-29 | — | — | US | disclosed |
| US-20060122345-A1 | Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and process for preparing polyolefins | BASSELL POLYOLEFINE GMBH (DE) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122345-A1 | Organometallic transition metal compound, biscyclopentadienyl ligand system, catalyst system and process for preparing polyolefins | C1R, CBR3, CBR1 | CYP1A2 1854/4885KDM4E 4210/4885ALDH1A1 3936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.