Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SLC2A4 | P14672 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | SLC2A8 | Q9NY64 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344602 | 0.90 | ALDH1A1 (0.58) | ALDH1A1NPSR1TDP1TSHRMEN1 | |
| SCHEMBL24343918 | 0.83 | KMT2A (0.52) | ALDH1A1NPSR1TDP1TSHRMEN1 | |
| SCHEMBL6820180 | 0.78 | TDP1 (0.56) | ALDH1A1NPSR1TDP1TSHRMEN1 | |
| SCHEMBL31345432 | 0.78 | TAS2R14 (0.46) | — | |
| SCHEMBL24344606 | 0.77 | SLC2A1 (0.56) | TSHRSLC2A1SLC2A4POLBLPAR1 | |
| SCHEMBL31345391 | 0.77 | APLNR (0.44) | MEN1KMT2A | |
| SCHEMBL25358359 | 0.75 | SLC2A1 (0.51) | ALDH1A1NPSR1TDP1TSHRMEN1 | |
| SCHEMBL10258703 | 0.75 | ALDH1A1 (0.46) | ALDH1A1TDP1MAPT | |
| SCHEMBL9827481 | 0.75 | KMT2A (0.56) | ALDH1A1NPSR1MEN1KMT2AMAPT | |
| SCHEMBL24343905 | 0.74 | SLC2A1 (0.51) | ALDH1A1NPSR1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601742-B2 | 4-(3-Hydroxy-4-methoxyphenyl)-pyrrolidin-2-one and derivatives; reverse transcriptase inhibitors; AIDS | IRM LLC (BM) | 2009-10-13 | — | — | US | disclosed |
| US-7495016-B2 | Pyrrolidones with anti-HIV activity | IRM LLC (BM) | 2009-02-24 | — | — | US | disclosed |
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2008-10-16 | — | — | US | disclosed |
| US-20040157859-A1 | Pyrrolidones with anti-HIV activity | IRM LLC, A DELAWARE LLC (BM) | 2004-08-12 | — | — | US | disclosed |
| WO-2004037784-A2 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | IRM LLC (BM) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255136-A1 | PYRROLIDONES WITH ANTI-HIV ACTIVITY | PREP, DHPS, PDCD11 | ALDH1A1 1894/4885NPSR1 2745/4885TDP1 1113/4885 |
| US-20040157859-A1 | Pyrrolidones with anti-HIV activity | PREP, DHPS, PDCD11 | ALDH1A1 1894/4885NPSR1 2745/4885TDP1 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.