Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3887010 | 0.80 | ALDH1A1 (0.65) | MEP1BALDH1A1 | |
| SCHEMBL13296438 | 0.78 | TSHR (0.63) | ALDH1A1LMNATHRBTSHRNPSR1 | |
| SCHEMBL13314764 | 0.76 | TSHR (0.61) | ALDH1A1LMNATSHRNPSR1SMN1; SMN2 | |
| SCHEMBL3885732 | 0.75 | MEP1B (0.52) | MEP1BALDH1A1MMP1LMNATHRB | |
| SCHEMBL27278034 | 0.75 | MEN1 (0.59) | ALDH1A1LMNATSHRNPSR1CYP3A4 | |
| SCHEMBL28677877 | 0.75 | KDM4E (0.71) | MEP1BALDH1A1MMP1LMNATSHR | |
| SCHEMBL6850445 | 0.74 | MEP1B (0.62) | MEP1BALDH1A1MMP1LMNATSHR | |
| SCHEMBL11883523 | 0.74 | CA1 (0.68) | ALDH1A1LMNATHRBTSHRNPSR1 | |
| 1,4-Dichlorobenzene SCHEMBL27511316 | 0.73 | ALDH1A1 (0.54) | ALDH1A1LMNACYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL6505407 | 0.73 | ALDH1A1 (0.68) | MEP1BALDH1A1MMP1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013184-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2008059238-A1 | BENZENESULFONAMIDE COMPOUNDS AS EDG-1 ANTAGONISTS USEFUL IN THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |
| WO-2007129019-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |