Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.53 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892574 | 0.80 | MEP1B (0.54) | ALDH1A1MEP1B | |
| SCHEMBL1287271 | 0.79 | ALDH1A1 (1.00) | ALDH1A1TP53GAAPRMT1TBXA2R | |
| SCHEMBL9661163 | 0.78 | TBXA2R (0.74) | ALDH1A1TP53GAATBXA2RMAPT | |
| SCHEMBL28539623 | 0.77 | L3MBTL1 (0.60) | ALDH1A1PRMT1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL27347377 | 0.77 | TBXA2R (0.84) | ALDH1A1TP53GAATBXA2RMAPT | |
| SCHEMBL1287281 | 0.76 | PRMT1 (0.83) | ALDH1A1TP53GAAPRMT1TBXA2R | |
| SCHEMBL13401886 | 0.74 | ALDH1A1 (0.65) | ALDH1A1TP53GAAPRMT1TBXA2R | |
| SCHEMBL10460529 | 0.74 | ALDH1A1 (0.72) | ALDH1A1TP53GAATBXA2RMAPT | |
| SCHEMBL5899482 | 0.74 | L3MBTL1 (0.60) | ALDH1A1TP53GAAPRMT1TBXA2R | |
| SCHEMBL8789480 | 0.73 | CYP19A1 (0.78) | ALDH1A1TP53GAAPRMT1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013184-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007129019-A1 | SULFONAMIDE COMPOUNDS USEFUL AS EDG RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |