Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HBB | P68871 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893257 | 0.83 | ALDH1A1 (0.70) | ALDH1A1TSHRALOX15HSD17B10MEN1 | |
| SCHEMBL3894901 | 0.81 | TSHR (0.69) | ALDH1A1TSHRALOX15HSD17B10MEN1 | |
| SCHEMBL3901081 | 0.76 | ALDH1A1 (0.55) | ALDH1A1TSHRALOX15HSD17B10MEN1 | |
| SCHEMBL24769038 | 0.72 | MTNR1A (0.53) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL556003 | 0.71 | KDM4E (0.55) | MEN1KMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL25522516 | 0.70 | KDM4E (0.47) | ALDH1A1TSHRMAPTLMNAADORA2A | |
| SCHEMBL4027176 | 0.69 | PKM (0.47) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL16028369 | 0.69 | GPR18 (0.55) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL17636795 | 0.68 | SMN1; SMN2 (0.43) | ALDH1A1TSHRMAPTLMNASMN1; SMN2 | |
| SCHEMBL3893344 | 0.67 | TSHR (0.64) | ALDH1A1TSHRALOX15HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495004-B2 | Purine derivatives as liver X receptor agonists | GLAXO GROUP LIMITED (GB) | 2009-02-24 | — | — | US | disclosed |
| US-7495004-B2 | Purine derivatives as liver X receptor agonists | GLAXO GROUP LIMITED (GB) | 2009-02-24 | — | — | US | disclosed |
| US-7495004-B2 | Purine derivatives as liver X receptor agonists | GLAXO GROUP LIMITED (GB) | 2009-02-24 | — | — | US | disclosed |
| US-20060094733-A1 | e.g. 7-(2-chloro-6-fluorobenzyl)-1,3-diethyl-8-piperidin-1-yl-3,7-dihydro-1H-purine-2,6-dione; maintenance of cholesterol balance; antidiabetic, diuretic, antihypertensive agent; insulin resistance, obesity; irritable bowel syndrome (IBS), Crohn's disease, ulcerative colitis | GLAXO GROUP LIMITED (GB) | 2006-05-04 | — | — | US | disclosed |
| EP-1521584-A1 | PURINE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004009091-A1 | PURINE DERIVATIVES AS LIVER X RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2004-01-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094733-A1 | e.g. 7-(2-chloro-6-fluorobenzyl)-1,3-diethyl-8-piperidin-1-yl-3,7-dihydro-1H-purine-2,6-dione; maintenance of cholesterol balance; antidiabetic, diuretic, antihypertensive agent; insulin resistance, obesity; irritable bowel syndrome (IBS), Crohn's disease, ulcerative colitis | NR1H2, GPR119, GPBAR1 | ALDH1A1 1429/4885TSHR 986/4885ALOX15 1489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.