Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 3/20 | 0.42 |
| ▸ | TACR3 | P29371 | 2/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5168073 | 0.95 | CCR2 (0.46) | BACE1CCR2HDAC3HDAC1HDAC2 | |
| Formic Acid SCHEMBL3894178 | 0.84 | ALDH1A1 (0.54) | BACE1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3899787 | 0.80 | TACR1 (0.43) | BACE1CCR2HDAC3HDAC1HDAC2 | |
| SCHEMBL5170508 | 0.79 | ALDH1A1 (0.58) | BACE1HDAC3HDAC1HDAC2HDAC6 | |
| Formic Acid SCHEMBL3898641 | 0.78 | CYP2C19 (0.41) | HDAC3HDAC1HDAC2HDAC6TACR3 | |
| SCHEMBL2932067 | 0.78 | ALDH1A1 (0.51) | CCR2HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL19280073 | 0.76 | ALDH1A1 (0.41) | BACE1HDAC1SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL28650686 | 0.76 | HDAC3 (0.51) | CCR2HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL23654370 | 0.76 | HDAC3 (0.53) | CCR2HDAC3HDAC1HDAC2HDAC6 | |
| Formic Acid SCHEMBL3895033 | 0.75 | PDE2A (0.47) | SLC6A4SLC6A3ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101006084-B | 4-arylmorpholin-3-one derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS | 2010-09-08 | — | — | CN | disclosed |
| US-7521449-B2 | 4-arylmorpholin-3-one derivatives, their preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2009-04-21 | — | — | US | disclosed |
| CN-101006084-A | 4-arylmorpholin-3-one derivatives, preparation method and therapeutic use thereof | SANOFI AVENTIS (FR) | 2007-07-25 | — | — | CN | disclosed |
| US-20070142349-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142349-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | ADRB3, ADRA2C, OPRK1 | BACE1 1083/4885CCR2 246/4885HDAC3 378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.