Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3904444 | 0.90 | HTT (0.41) | HTTTP53SMN1; SMN2MCHR1ACHE | |
| SCHEMBL3914346 | 0.75 | HTT (0.54) | HTTTP53SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL3906448 | 0.71 | HTT (0.46) | HTTPOLB | |
| SCHEMBL13868377 | 0.68 | BRD4 (0.50) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL13868378 | 0.68 | BRD4 (0.60) | ALDH1A1 | |
| SCHEMBL3911313 | 0.66 | DPP4 (0.55) | HTTTP53SMN1; SMN2MCHR1ALDH1A1 | |
| SCHEMBL2900478 | 0.65 | TP53 (0.44) | HTTTP53SMN1; SMN2MCHR1ALDH1A1 | |
| SCHEMBL15858005 | 0.65 | ALDH1A1 (0.53) | HTTTP53SMN1; SMN2MCHR1ACHE | |
| SCHEMBL2899609 | 0.64 | TP53 (0.44) | HTTTP53SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL27685281 | 0.63 | TP53 (0.62) | HTTTP53MCHR1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20060024330-A1 | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060024330-A1 | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors | DHPS, DUT, CDKN1A | HTT 4666/4885TP53 477/4885SMN1; SMN2 3798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.