Sugi Predict

Sugi Predict / Compounds / SCHEMBL3908975

SCHEMBL3908975

SCHEMBL3908975

CN(Cc1ccc(F)cc1Cl)C(=O)c1ccccc1NS(=O)(=O)C1=CC=CN2SNC=C12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.38
▸ MEN1 O00255 3/20 0.38
▸ POLB P06746 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ TDP1 Q9NUW8 1/20 0.34
▸ KDM4E B2RXH2 4/20 0.33
▸ ALDH1A1 P00352 3/20 0.33
▸ LIMK2 P53671 1/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ HPGD P15428 1/20 0.33
▸ NPY1R P25929 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ NPY2R P49146 1/20 0.33
▸ PAX8 Q06710 1/20 0.33
▸ RCE1 Q9Y256 1/20 0.33
▸ CCKBR P32239 1/20 0.32
▸ CRHBP P24387 1/20 0.32
▸ CRHR2 Q13324 1/20 0.32
▸ PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3907650 0.93 KMT2A (0.39) KMT2AMEN1POLBGAATDP1
SCHEMBL3906684 0.92 CRHBP (0.39) KMT2AMEN1POLBGAATDP1
SCHEMBL3902440 0.92 CCKBR (0.38) KMT2AMEN1ALDH1A1MAPTHPGD
SCHEMBL3902433 0.92 CRHBP (0.36) KMT2AMEN1ALDH1A1MAPTHTT
SCHEMBL3907638 0.91 KMT2A (0.34) KMT2AMEN1SMN1; SMN2MAPTCCKBR
SCHEMBL3913074 0.90 MEN1 (0.32) KMT2AMEN1CCKBRCRHBPCRHR2
SCHEMBL3900812 0.90 MEN1 (0.32) KMT2AMEN1CCKBRCRHBPCRHR2
SCHEMBL3906317 0.86 CCR2 (0.39) KMT2AMEN1ALDH1A1MAPTHTT
SCHEMBL3915008 0.86 CCR2 (0.37) KMT2AMEN1ALDH1A1MAPTHTT
SCHEMBL3900087 0.86 ALDH1A1 (0.43) KMT2AMEN1POLBKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7241759-B2 Benzo[1,2,5]thiadiazole compounds JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-10 — — US claimed
US-7550492-B2 Benzo[1,2,5]thiadiazole compounds JANSSEN PHARMACEUTICA N.V. (BE) 2009-06-23 — — US disclosed
US-20070276016-A1 BENZO[1,2,5]THIADIAZOLE COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-29 — — US disclosed
US-7241759-B2 Benzo[1,2,5]thiadiazole compounds JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-10 — — US disclosed
EP-1675837-A2 BENZO [1,2,5] THIADIAZOLE COMPOUNDS AS CCK2 MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-05 — — EP disclosed
WO-2005012275-A2 BENZO [1, 2, 5] THIADIAZOLE COMPOUNDS AS CCK2 MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-02-10 — — WO disclosed
US-20040224983-A1 Benzo[1,2,5]thiadiazole compounds JANSSEN PHARMACEUTICA, N.V. (BE) 2004-11-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070276016-A1 BENZO[1,2,5]THIADIAZOLE COMPOUNDS CCKBR, CCKAR, GIPR KMT2A 3053/4885MEN1 2768/4885POLB 4576/4885
US-20040224983-A1 Benzo[1,2,5]thiadiazole compounds CCKBR, CCKAR, BRSK2 KMT2A 3281/4885MEN1 2441/4885POLB 4671/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.