SCHEMBL3914716

SCHEMBL3914716

C[Si](C)(CCl)Oc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA4 P22748 1/20 0.39
LTA4H P09960 4/20 0.36
TSHR P16473 1/20 0.36
KCNA3 P22001 1/20 0.36
HTR1B P28222 2/20 0.33
KCNH2 Q12809 1/20 0.33
LMNA P02545 1/20 0.33
TTR P02766 1/20 0.33
HTR1D P28221 1/20 0.33
TAAR1 Q96RJ0 2/20 0.33
TDP1 Q9NUW8 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RECQL P46063 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2526127 0.88 MEN1 (0.33) LMNATDP1
SCHEMBL5818514 0.84 HIF1A (0.34) TSHRLMNATAAR1TDP1ALDH1A1
SCHEMBL3924741 0.82 LTA4H (0.42) CA4LTA4HTSHRKCNA3LMNA
SCHEMBL707221 0.81 CA4 (0.42) CA4LTA4HTSHRKCNA3HTR1B
SCHEMBL710740 0.81 CA4 (0.42) CA4LTA4HTSHRKCNA3HTR1B
SCHEMBL3923699 0.79 KCNA3 (0.40) CA4LTA4HTSHRKCNA3HTR1B
SCHEMBL2526125 0.79 CA1 (0.36) CA4TSHRLMNATDP1ALDH1A1
SCHEMBL19816761 0.79 LTA4H (0.40) CA4LTA4HTSHRKCNA3HTR1B
SCHEMBL23930415 0.77 ALDH1A1 (0.41) CA4LTA4HTSHRKCNA3KCNH2
SCHEMBL703963 0.77 KCNA3 (0.41) CA4LTA4HTSHRKCNA3HTR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103665043-A Tenofovir prodrug and application thereof in medicine UNITRIS BIOPHARMA CO LTD 2014-03-26 CN disclosed
US-7619108-B2 Process for preparing unsaturated organosilicon compounds WACKER CHEMIE AG (DE) 2009-11-17 US disclosed
EP-1954701-B1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER CHEMIE AG (DE) 2009-03-18 EP disclosed
US-20080293958-A1 Process for Preparing Unsaturated Organosilicon Compounds WACKER CHEMIE AG (DE) 2008-11-27 US disclosed
US-6815554-B2 REACTING A HALOALKYLSILANE WITH A SALT OF AN UNSATURATED CARBOXYLIC ACID IN THE PRESENCE OF A PHASE TRANSFER CATALYST; BONDING AGENTS WACKER-CHEMIE GMBH (DE) 2004-11-09 US disclosed
US-20020151736-A1 PROCESS FOR PREPARING UNSATURATED ORGANOSILICON COMPOUNDS WACKER-CHEMIE GMBH (DE) 2002-10-17 US disclosed
EP-1249454-A1 Preparation of unsaturated organo-silicon compounds Wacker-Chemie GmbH (DE) 2002-10-16 EP disclosed
EP-0700951-B1 Polyorganosiloxane and process for producing the same SHOWA DENKO KK (JP) 2000-12-27 EP disclosed
US-5622784-A WATERPROOFING; MODIFIED SILICON DIOXIDE THIN FILM SEIKO EPSON CORPORATION (JP) 1997-04-22 US disclosed
EP-0700951-A1 Polyorganosiloxane and process for producing the same SHOWA DENKO KABUSHIKI KAISHA (JP) 1996-03-13 EP disclosed
US-5491203-A COMPRISES POLYSILSESQUIOXANE STRUCTURE; HAS METHYL GROUP AND A REACTIVE GROUP ON SIDE CHAINS; SUITABLE AS POLYMER MODIFIER; CROSSLINKING; COATINGS SHOWA DENKO K. K. (JP) 1996-02-13 US disclosed
EP-0455269-B1 Packing for use in resolution DAICEL CHEM (JP) 1993-11-10 EP disclosed
EP-0455269-A1 Packing for use in resolution DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1991-11-06 EP disclosed
EP-0150221-B1 PACKING FOR USE IN SEPARATION DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1990-08-08 EP disclosed
EP-0318469-A1 Packing for use in resolution DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1989-05-31 EP disclosed
US-4627919-A Resolving agent DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1986-12-09 US disclosed
US-4619984-A MODIFIED SILICA GEL DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1986-10-28 US disclosed
EP-0150221-A1 PACKING FOR USE IN SEPARATION DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1985-08-07 EP disclosed