Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.81 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915235 | 0.90 | TUBB1 (1.00) | TUBB1AKR1C3AKR1C2ALDH1A1L3MBTL1 | |
| SCHEMBL5636786 | 0.79 | TUBB1 (0.54) | TUBB1ALDH1A1L3MBTL1TUBB4ATUBB | |
| SCHEMBL11613879 | 0.78 | TUBB1 (0.75) | TUBB1AKR1C3AKR1C2ALDH1A1L3MBTL1 | |
| SCHEMBL3919337 | 0.75 | TUBB1 (1.00) | TUBB1ALDH1A1L3MBTL1TUBB4ATUBB | |
| SCHEMBL5635961 | 0.73 | TUBB1 (0.47) | TUBB1ALDH1A1L3MBTL1TUBB4ATUBB | |
| SCHEMBL16746715 | 0.72 | AKR1C3 (0.81) | TUBB1AKR1C3AKR1C2ALDH1A1L3MBTL1 | |
| SCHEMBL12685163 | 0.72 | NR1H2 (0.49) | TUBB1AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL29941900 | 0.70 | AKR1C3 (0.77) | TUBB1AKR1C3AKR1C2ALDH1A1L3MBTL1 | |
| SCHEMBL29481380 | 0.70 | AKR1C3 (1.00) | TUBB1AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL11037919 | 0.70 | AKR1C3 (1.00) | TUBB1AKR1C3AKR1C2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | claimed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | claimed |
| US-20050267194-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | claimed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7632955-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-12-15 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-7528165-B2 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2009-05-05 | — | — | US | disclosed |
| US-20050267108-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | disclosed |
| US-20050267194-A1 | Indole compounds | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2005-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050267108-A1 | Indole compounds | TUBB1, TUBB3, TUBB | TUBB1 1/4885AKR1C3 488/4885AKR1C2 487/4885 |
| US-20050267194-A1 | Indole compounds | TUBB1, TUBB, TUBB3 | TUBB1 1/4885AKR1C3 407/4885AKR1C2 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.