Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743016 | 0.77 | MCL1 (0.59) | MCL1ALDH1A1KMT2ABCL2MDM2 | |
| SCHEMBL2908545 | 0.76 | MCL1 (0.53) | MCL1ALDH1A1KMT2ABCL2MDM2 | |
| SCHEMBL794416 | 0.76 | MCL1 (0.58) | MCL1ALDH1A1KMT2ABCL2MDM2 | |
| SCHEMBL523239 | 0.73 | EGLN1 (0.50) | MCL1ALDH1A1KMT2APRKAB2PRKAG1 | |
| SCHEMBL522422 | 0.70 | EGLN1 (0.45) | MCL1ALDH1A1KMT2APRKAB2PRKAG1 | |
| SCHEMBL5936887 | 0.69 | PRKAB2 (0.37) | MCL1ALDH1A1KMT2AKMOPRKAB2 | |
| SCHEMBL29196801 | 0.69 | ALDH1A1 (0.52) | MCL1ALDH1A1KMT2AALOX15CYP1A2 | |
| SCHEMBL3915436 | 0.68 | ALDH1A1 (0.46) | MCL1ALDH1A1KMT2APRKAB2PRKAG1 | |
| SCHEMBL4078616 | 0.68 | EGLN1 (0.41) | MCL1ALDH1A1KMT2APRKAB2PRKAG1 | |
| SCHEMBL2816376 | 0.66 | KMO (0.49) | MCL1ALDH1A1KMT2AKMOALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035000-A1 | HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER | FIBROGEN, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146438-A1 | HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER | FIBROGEN, INC. (US) | 2007-12-21 | — | — | WO | disclosed |