Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | GCK | P35557 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31430800 | 0.78 | ALDH1A1 (0.56) | ALDH1A1EGLN1KMT2AMCL1PRKAB2 | |
| SCHEMBL5146422 | 0.69 | ABL1 (0.42) | ALDH1A1EGLN1MCL1ABL1 | |
| SCHEMBL3915432 | 0.68 | MCL1 (0.44) | ALDH1A1KMT2AMCL1PRKAB2PRKAG1 | |
| SCHEMBL620760 | 0.68 | ALDH1A1 (0.51) | ALDH1A1KMT2AMCL1PRKAB2PRKAG1 | |
| SCHEMBL1316975 | 0.68 | ALDH1A1 (0.73) | ALDH1A1KMT2AMCL1 | |
| SCHEMBL5936887 | 0.68 | PRKAB2 (0.37) | ALDH1A1EGLN1KMT2AMCL1PRKAB2 | |
| SCHEMBL1793961 | 0.67 | ALDH1A1 (0.67) | ALDH1A1KMT2AMCL1KDM4C | |
| SCHEMBL31430857 | 0.67 | ALDH1A1 (0.41) | ALDH1A1EGLN1P2RX3ABL1 | |
| SCHEMBL28054675 | 0.67 | ALDH1A1 (0.53) | ALDH1A1EGLN1KMT2AMCL1KDM4C | |
| SCHEMBL15935967 | 0.67 | ALDH1A1 (0.71) | ALDH1A1KMT2AMCL1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035000-A1 | HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER | FIBROGEN, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146438-A1 | HIF HYDROXYLASE INHIBITORS FOR TREATMENT OF ANEMIA OF CANCER | FIBROGEN, INC. (US) | 2007-12-21 | — | — | WO | disclosed |