Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 5/20 | 0.68 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.68 |
| ▸ | HTR3B | O95264 | 3/20 | 0.68 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.68 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.68 |
| ▸ | CA2 | P00918 | 3/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA9 | Q16790 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 3/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679015 | 0.83 | HTR3A (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3916736 | 0.81 | HTR3A (0.66) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| [11C]Phenethylguanidine SCHEMBL837645 | 0.80 | HTR3A (0.80) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL14763877 | 0.79 | HTR3A (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3925719 | 0.78 | ALOX15 (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL4094076 | 0.77 | GRIN2D (0.54) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL20681016 | 0.77 | ESR1 (0.65) | HTR3ACA2ESR1ESR2ADRA2A | |
| SCHEMBL7381623 | 0.77 | ESR1 (0.65) | HTR3ACA2ESR1ESR2ADRA2A | |
| SCHEMBL3926082 | 0.76 | HTR3A (0.69) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3929410 | 0.76 | HTR3E (0.59) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060127309-A1 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-06-15 | — | — | US | claimed |
| US-10259781-B2 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170190658-A1 | IMAGING AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-07-06 | — | — | US | disclosed |
| CN-106138803-A | A kind of pharmaceutical composition treating old dryness of the intestine disease and preparation method thereof | 济南星懿医药技术有限公司 | 2016-11-23 | — | — | CN | disclosed |
| US-20150246142-A1 | IMAGING AGENTS | UNIV MICHIGAN (US) | 2015-09-03 | — | — | US | disclosed |
| US-7534418-B2 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060127309-A1 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246142-A1 | IMAGING AGENTS | SLC18A1, VHL, GDI1 | HTR3A 51/4885HTR3E 77/4885HTR3B 82/4885 |
| US-20060127309-A1 | Imaging agents | MPI, NPC1, NPC1L1 | HTR3A 2660/4885HTR3E 1509/4885HTR3B 1609/4885 |
| US-10259781-B2 | Imaging agents | SLC18A1, VHL, GDI1 | HTR3A 51/4885HTR3E 77/4885HTR3B 82/4885 |
| US-20170190658-A1 | IMAGING AGENTS | SLC18A1, VHL, GDI1 | HTR3A 51/4885HTR3E 77/4885HTR3B 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.