Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 7/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 4/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3916794 | 0.98 | NOS1 (0.44) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3917423 | 0.98 | NOS1 (0.46) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL3917421 | 0.98 | NOS1 (0.46) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8094745 | 0.84 | ALDH1A1 (0.40) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8094742 | 0.84 | ALDH1A1 (0.40) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL20349667 | 0.83 | MEN1 (0.37) | NOS1MEN1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL817480 | 0.83 | PAX8 (0.35) | MEN1KMT2AMAPTHTTPLAU | |
| Hydrochloric Acid SCHEMBL811295 | 0.83 | PAX8 (0.35) | MEN1KMT2AMAPTHTTPLAU | |
| Hydrochloric Acid SCHEMBL7176154 | 0.80 | PAX8 (0.35) | MEN1KMT2AMAPTHTTPLAU | |
| Hydrochloric Acid SCHEMBL7177207 | 0.80 | PAX8 (0.35) | MEN1KMT2AMAPTHTTPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919850-B1 | NITRO SUBSTITUTED ALPHA-OLEFIN SYNTHESIS CATALYSTS | DU PONT (US) | 2009-03-18 | — | — | EP | disclosed |