SCHEMBL3920722

SCHEMBL3920722

c1ccc(SCN2CCCC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.51
NPC1 O15118 3/20 0.51
RAB9A P51151 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
LTA4H P09960 3/20 0.50
KMT2A Q03164 3/20 0.49
MEN1 O00255 2/20 0.49
CHRNA7 P36544 1/20 0.49
MAPK1 P28482 1/20 0.46
SLC6A3 Q01959 1/20 0.45
LMNA P02545 1/20 0.45
HPGD P15428 1/20 0.45
SIGMAR1 Q99720 1/20 0.44
FFAR1 O14842 1/20 0.43
CHRNB2 P17787 1/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA4 P43681 1/20 0.43
HTT P42858 1/20 0.43
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1930719 0.98 ALDH1A1 (0.50) ALDH1A1NPC1RAB9ASMN1; SMN2LTA4H
Hydrochloric Acid SCHEMBL11272257 0.96 KMT2A (0.50) ALDH1A1NPC1RAB9ASMN1; SMN2LTA4H
SCHEMBL9813060 0.82 KMT2A (0.45) ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL9813063 0.82 SIGMAR1 (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL9813058 0.82 SIGMAR1 (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL19273423 0.79 LTA4H (0.75) ALDH1A1NPC1RAB9ASMN1; SMN2LTA4H
SCHEMBL11536449 0.78 LTA4H (0.73) ALDH1A1NPC1RAB9ASMN1; SMN2LTA4H
Hydrochloric Acid SCHEMBL11537843 0.76 LTA4H (0.71) ALDH1A1NPC1RAB9ASMN1; SMN2LTA4H
SCHEMBL491576 0.75 KDM4E (0.64) ALDH1A1LTA4HKMT2AMEN1SIGMAR1
Hydrochloric Acid SCHEMBL11591663 0.74 MAPT (0.58) ALDH1A1RAB9AKMT2AMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1590360-A4 PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES IND RES LTD (NZ) 2009-06-24 EP disclosed
EP-1590360-A1 PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES INDUSTRIAL RESEARCH LIMITED (NZ) 2005-11-02 EP disclosed
WO-2004069856-A1 PROCESS FOR PREPARING INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES INDUSTRIAL RESEARCH LIMITED (NZ) 2004-08-19 WO disclosed
EP-0711290-A1 METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES SANOFI (FR) 1996-05-15 EP disclosed
WO-1995004052-A1 METHYLGUANIDINE DERIVATIVES, METHODS FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAID DERIVATIVES SANOFI (FR) 1995-02-09 WO disclosed