Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930203 | 0.85 | HTR2C (0.42) | HTR2CLMNASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL1561077 | 0.84 | ACHE (0.49) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL1561101 | 0.84 | ACHE (0.49) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL3933066 | 0.78 | HTR2C (0.47) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL578453 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL16934132 | 0.78 | ALDH1A1 (0.47) | HTR2CLMNASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL5262282 | 0.78 | MTNR1A (0.44) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL2850199 | 0.78 | HTR2C (0.47) | HTR2CLMNASMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL2543696 | 0.78 | ALDH1A1 (0.63) | MEN1KMT2AHTR2CLMNASMN1; SMN2 | |
| SCHEMBL11672124 | 0.76 | MEN1 (0.46) | MEN1KMT2ALMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |