Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3922657 | 0.85 | MEN1 (0.45) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL1561101 | 0.83 | ACHE (0.49) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL1561077 | 0.83 | ACHE (0.49) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL2850199 | 0.80 | HTR2C (0.47) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL5263828 | 0.80 | SLC7A5 (0.38) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL666891 | 0.78 | KDM4E (0.35) | SMN1; SMN2LMNAALDH1A1MAPTPTGS1 | |
| SCHEMBL3933066 | 0.77 | HTR2C (0.47) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL5262282 | 0.77 | MTNR1A (0.44) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL578453 | 0.77 | ALDH1A1 (0.47) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 | |
| SCHEMBL16934132 | 0.77 | ALDH1A1 (0.47) | HTR2CSMN1; SMN2LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |