Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 16/20 | 1.00 |
| ▸ | ESR1 | P03372 | 15/20 | 1.00 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929813 | 0.93 | ESR2 (1.00) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL8233865 | 0.84 | ESR2 (0.82) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL8234840 | 0.84 | ESR2 (0.71) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL8215899 | 0.81 | ESR2 (0.69) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL8235581 | 0.81 | ESR2 (0.77) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL3575957 | 0.80 | FGFR1 (0.70) | ESR2ESR1MAOAUGT1A1MAOB | |
| SCHEMBL3928878 | 0.80 | ESR2 (1.00) | ESR2ESR1ALOX5MMP3BCL2L1 | |
| SCHEMBL25617591 | 0.79 | ESR1 (0.65) | ESR2ESR1MMP3BCL2L1 | |
| SCHEMBL22127728 | 0.79 | ESR1 (0.65) | ESR2ESR1MMP3BCL2L1 | |
| SCHEMBL17338680 | 0.79 | ESR1 (0.65) | ESR2ESR1MMP3BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009417-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-15 | — | — | WO | claimed |
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-08 | — | — | US | claimed |
| US-6903238-B2 | Substituted indenones as estrogenic agents | WYETH (US) | 2005-06-07 | — | — | US | claimed |
| US-20030166643-A1 | Substituted indenones as estrogenic agents | WYETH | 2003-09-04 | — | — | US | claimed |
| WO-2009009417-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-15 | — | — | WO | disclosed |
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| US-6903238-B2 | Substituted indenones as estrogenic agents | WYETH (US) | 2005-06-07 | — | — | US | disclosed |
| US-20030166643-A1 | Substituted indenones as estrogenic agents | WYETH | 2003-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090010884-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | COL2A1, COL1A1, COL14A1 | ESR2 5/4885ESR1 4/4885MAOA 1145/4885 |
| US-20030166643-A1 | Substituted indenones as estrogenic agents | GPER1, ESR2, ESR1 | ESR2 2/4885ESR1 3/4885MAOA 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.