Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361040 | 1.00 | PIN1 (0.37) | PIN1APPHIF1APDE4APDE4B | |
| SCHEMBL14408050 | 1.00 | PIN1 (0.37) | PIN1APPHIF1APDE4APDE4B | |
| SCHEMBL14408048 | 1.00 | PIN1 (0.37) | PIN1APPHIF1APDE4APDE4B | |
| SCHEMBL3669336 | 0.85 | PIN1 (0.39) | PIN1APPHIF1APDE4APDE4B | |
| SCHEMBL3668993 | 0.85 | PIN1 (0.39) | PIN1APPHIF1APDE4APDE4B | |
| SCHEMBL14380399 | 0.84 | MEN1 (0.42) | APPHIF1APDE4APDE4BPDE4C | |
| SCHEMBL14626184 | 0.83 | SLC5A2 (0.35) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14415238 | 0.83 | SLC5A2 (0.35) | HIF1APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4620243 | 0.83 | SIRT1 (0.38) | PIN1APPCYP4F2CYP4A11BCHE | |
| SCHEMBL14408042 | 0.83 | APP (0.39) | PIN1APPHIF1APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507831-B2 | Tetra- and penta-o-benzyl-protected, C-4 activated-epicatechin and -catechin monomers and processes for their preparation and use | MARS, INC. | 2009-03-24 | — | — | US | claimed |
| US-20080306286-A1 | Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof | PROTAMED, INC. | 2008-12-11 | — | — | US | claimed |
| EP-1921076-A1 | systhesis of procyanidin B2 | Proteotech Inc. (US) | 2008-05-14 | — | — | EP | claimed |
| EP-1896444-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4 , 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES | MARS, INCORPORATED (US) | 2008-03-12 | — | — | EP | claimed |
| US-20070276147-A1 | Synthesis of Oligomeric Epicatechin- and Catechin-Derived Procyanidins | KOZIKOWSKI ALAN P | 2007-11-29 | — | — | US | claimed |
| US-7244855-B2 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins | MARS, INC. | 2007-07-17 | — | — | US | claimed |
| WO-2007005248-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4β, 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES | MARS, INCORPORATED (US) | 2007-01-11 | — | — | WO | claimed |
| US-20070004796-A1 | Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates | MARS, INC. | 2007-01-04 | — | — | US | claimed |
| US-20060173198-A1 | Synthesis of dimeric, trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having 4beta,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest | KOZIKOWSKI ALAN P | 2006-08-03 | — | — | US | claimed |
| EP-1554270-A2 | ISOLATION, PURIFICATION AND SYNTHESIS OF PROCYANIDIN B2 AND USES THEREOF | Proteotech, Inc. (US) | 2005-07-20 | — | — | EP | claimed |
| US-20050020512-A1 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins | MARS, INCORPORATED | 2005-01-27 | — | — | US | claimed |
| US-20040116718-A1 | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4beta,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest | MARS, INC. | 2004-06-17 | — | — | US | claimed |
| WO-2004033448-A2 | ISOLATION, PURIFICATION AND SYNTHESIS OF PROCYANIDIN B2 AND USES THEREOF | PROTEOTECH, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| US-9133176-B2 | Isolation, purification and synthesis of procyanidin B2 and uses thereof | PROTEOTECH INC. (US) | 2015-09-15 | — | — | US | disclosed |
| US-7507831-B2 | Tetra- and penta-o-benzyl-protected, C-4 activated-epicatechin and -catechin monomers and processes for their preparation and use | MARS, INC. | 2009-03-24 | — | — | US | disclosed |
| US-20080306142-A1 | Isolation, purification and synthesis of procyanidin B2 and uses thereof | COGNITIVE CLARITY INC. | 2008-12-11 | — | — | US | disclosed |
| US-6720432-B2 | OXIDIZING HYDROXYL-PROTECTED BENZYLEPITCATECHIN, ADDING NUCLEOPHILIC ARYL-ORGANOMETALLIC REAGENT, AND DEOXYGENATING FORMING COMPOUNDS SUCH AS 3,5,7,3',4'-PENTA-O-BENZYL-4-HYDROXYEPICATECHIN; PROCYANIDINS | MARS INCORPORATED | 2004-04-13 | — | — | US | disclosed |
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | MARS INCORPORATED | 2003-05-29 | — | — | US | disclosed |
| US-6476241-B1 | Synthesis of 4α-arylepicatechins | MARS INCORPORATED | 2002-11-05 | — | — | US | disclosed |
| US-6207842-B1 | FROM EPICATECHIN | MARS INCORPORATED | 2001-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | FABP4, TEAD4, FABP7 | PIN1 3735/4885APP 4510/4885HIF1A 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.