Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30785051 | 0.90 | MAPT (0.69) | MAPTHTTNPSR1GAATP53 | |
| SCHEMBL30785080 | 0.86 | MAPT (0.46) | MAPTHTTNPSR1GAATP53 | |
| SCHEMBL11576626 | 0.85 | MAPT (0.78) | MAPTHTTNPSR1GAAALDH1A1 | |
| SCHEMBL17193969 | 0.84 | MAPT (0.58) | MAPTHTTNPSR1GAAALDH1A1 | |
| SCHEMBL3964231 | 0.83 | TP53 (0.66) | MAPTHTTNPSR1GAATP53 | |
| SCHEMBL30785077 | 0.83 | TP53 (0.66) | MAPTHTTNPSR1GAATP53 | |
| SCHEMBL9212883 | 0.83 | PTGDR2 (0.57) | MAPTGAATP53SMN1; SMN2KMT2A | |
| SCHEMBL9726812 | 0.82 | ACHE (0.58) | MAPTHTTNPSR1GAATP53 | |
| SCHEMBL5988932 | 0.82 | MAPT (0.55) | MAPTHTTNPSR1GAAALDH1A1 | |
| SCHEMBL14099187 | 0.81 | LMNA (0.50) | MAPTHTTTP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090176841-A1 | NOVEL 6-5 SYSTEM BICYCLIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 2009-07-09 | — | — | US | disclosed |
| EP-2036887-A1 | NOVEL 6-5 BICYCIC HETEROCYCLIC DERIVATIVE AND MEDICAL USE THEREOF | Sanwa Kagaku Kenkyusho Co., Ltd (JP) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176841-A1 | NOVEL 6-5 SYSTEM BICYCLIC HETEROCYCLIC DERIVATIVE AND ITS PHARMACEUTICAL UTILITY | TSHR, TRHR, THRA | MAPT 4643/4885HTT 1540/4885NPSR1 154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.