Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 5/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26655868 | 0.83 | APAF1 (0.67) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL5280394 | 0.81 | MAPT (1.00) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL12280399 | 0.80 | P2RX7 (0.69) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL4446477 | 0.79 | P2RX7 (0.73) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL10068409 | 0.79 | P2RX7 (0.74) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL9176577 | 0.78 | SENP1 (1.00) | P2RX7SENP1ESR1ESR2 | |
| Anthraquinone SCHEMBL10924432 | 0.78 | MEN1 (0.71) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7101602 | 0.77 | FGFR1 (0.57) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL29630331 | 0.76 | P2RX7 (0.76) | P2RX7MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL3691126 | 0.74 | P2RX7 (0.56) | P2RX7MAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009417-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF PREVENTING, TREATING, OR INHIBITING INFLAMMATORY DISEASES, DISORDERS, OR CONDITIONS OF THE SKIN, AND DISEASES, DISORDERS, OR CONDITIONS ASSOCIATED WITH COLLAGEN DEPLETION | WYETH (US) | 2009-01-15 | — | — | WO | disclosed |