Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA7 | P43166 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3935962 | 0.89 | CA12 (0.48) | CA12CA1CA2CA7CA9 | |
| SCHEMBL24317651 | 0.79 | NUDT1 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6586612 | 0.77 | CCR6 (0.53) | ALDH1A1SMN1; SMN2TSHRKDM4EKMT2A | |
| SCHEMBL29923210 | 0.74 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRIKBKBKDM4E | |
| SCHEMBL24915691 | 0.74 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2TSHRIKBKBKDM4E | |
| SCHEMBL9505270 | 0.73 | TSHR (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL29923655 | 0.72 | ALDH1A1 (0.44) | CA12CA2CA7CA9CA14 | |
| SCHEMBL24916324 | 0.72 | ALDH1A1 (0.44) | CA12CA2CA7CA9CA14 | |
| SCHEMBL1795334 | 0.71 | TARBP2 (0.44) | CA12CA1CA2CA7CA9 | |
| SCHEMBL9736115 | 0.71 | TSHR (0.55) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009008552-A1 | 8-ARYL-4-ALKYLPYRROLO[2,3,4-DE]QUINOLIN-5(4H)-ONE AND 8-ARYL-4-ALKYL-4,5-DIHYDROPYRROLO[2,3,4-DE]QUINOLIN-5-OL DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2009-01-15 | — | — | WO | disclosed |