Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ADH1B | P00325 | 1/20 | 0.30 |
| ▸ | ADH1C | P00326 | 1/20 | 0.30 |
| ▸ | ADH1A | P07327 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365418 | 0.84 | MMP1 (0.34) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL3935406 | 0.80 | ADH1B (0.37) | ALDH1A1MAPTADH1BADH1CADH1A | |
| SCHEMBL3925051 | 0.78 | KDM4E (0.33) | ALDH1A1MAPTADH1BADH1CADH1A | |
| SCHEMBL5911087 | 0.77 | KMT2A (0.39) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL3928119 | 0.77 | SIGMAR1 (0.33) | ADH1BADH1CADH1A | |
| SCHEMBL5565559 | 0.76 | SMN1; SMN2 (0.40) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL7185320 | 0.74 | HTT (0.38) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL3670816 | 0.73 | ALDH1A1 (0.38) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL15732428 | 0.73 | ALDH1A1 (0.45) | ALDH1A1KMT2ARAB9AMAPTLMNA | |
| SCHEMBL15515534 | 0.72 | ALDH1A1 (0.40) | ALDH1A1KMT2ARAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |