Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 2/20 | 0.37 |
| ▸ | ADH1C | P00326 | 2/20 | 0.37 |
| ▸ | ADH1A | P07327 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADH4 | P08319 | 1/20 | 0.31 |
| ▸ | ADH7 | P40394 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366123 | 0.84 | ADH1B (0.36) | ADH1BADH1CADH1AADH4ADH7 | |
| SCHEMBL3925051 | 0.82 | KDM4E (0.33) | ADH1BADH1CADH1AALDH1A1MAPT | |
| SCHEMBL3929786 | 0.80 | ALDH1A1 (0.38) | ADH1BADH1CADH1AALDH1A1MAPT | |
| SCHEMBL3928119 | 0.80 | SIGMAR1 (0.33) | ADH1BADH1CADH1A | |
| SCHEMBL5911214 | 0.75 | ALDH1A1 (0.33) | ALDH1A1MAPTFDPS | |
| SCHEMBL5240072 | 0.74 | ADH1B (0.46) | ADH1BADH1CADH1AFDPS | |
| SCHEMBL5910690 | 0.72 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| SCHEMBL5556768 | 0.71 | ADH1B (0.48) | ADH1BADH1CADH1A | |
| SCHEMBL1487937 | 0.70 | — | — | |
| SCHEMBL12522742 | 0.70 | MAPT (0.32) | ALDH1A1MAPTFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | claimed |
| WO-2009141738-A2 | MODIFIED DRUGS FOR USE IN LIPOSOMAL NANOPARTICLES | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009007390-A2 | 2-PYRAZ INYLBENZ IMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |