Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1A | P07327 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADH1C | P00326 | 4/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ADH4 | P08319 | 1/20 | 0.32 |
| ▸ | SHBG | P04278 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28083249 | 0.94 | ADH1A (0.39) | ADH1ACYP1A2ADH1CADH1BDRD2 | |
| SCHEMBL17914487 | 0.88 | ADH1A (0.47) | ADH1AADH1CADH1BDRD2DRD3 | |
| SCHEMBL17914491 | 0.85 | ADH1A (0.45) | ADH1AADH1CADH1BDRD2DRD3 | |
| SCHEMBL19879075 | 0.83 | ADH1A (0.37) | ADH1ACYP1A2ADH1CADH1BTHRA | |
| SCHEMBL735434 | 0.82 | ADH1A (0.37) | ADH1AADH1CADH1B | |
| SCHEMBL14355686 | 0.82 | ADH1A (0.37) | ADH1AADH1CADH1BDRD2DRD3 | |
| SCHEMBL27420655 | 0.82 | ADH1A (0.37) | ADH1AADH1CADH1BMEN1ALDH1A1 | |
| SCHEMBL736907 | 0.80 | ADH1B (0.34) | ADH1AADH1CADH1B | |
| SCHEMBL17914492 | 0.79 | ADH1A (0.41) | ADH1AADH1CADH1BSHBGMEN1 | |
| SCHEMBL13503176 | 0.79 | ADH1A (0.43) | ADH1AADH1CADH1BSHBGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895330-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-20 | — | — | US | disclosed |
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |
| US-9758492-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160200674-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-07-14 | — | — | US | disclosed |
| US-20160143870-A1 | IDO INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-05-26 | — | — | US | disclosed |
| US-9079824-B2 | Method for the synthesis of an amino acetal | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2015-07-14 | — | — | US | disclosed |
| US-20130165682-A1 | METHOD FOR THE SYNTHESIS OF AN AMINO ACETAL | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2013-06-27 | — | — | US | disclosed |
| WO-2012005693-A1 | METHOD FOR THE SYNTHESIS OF AN AMINO ACETAL | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160143870-A1 | IDO INHIBITORS | IDO1, IDO2, TDO2 | ADH1A 1519/4885CYP1A2 204/4885ADH1C 1839/4885 |
| US-20160200674-A1 | IDO INHIBITORS | IDO1, IDO2, INMT | ADH1A 3056/4885CYP1A2 1032/4885ADH1C 3227/4885 |
| US-20130165682-A1 | METHOD FOR THE SYNTHESIS OF AN AMINO ACETAL | AOX1, DAO, ALDH7A1 | ADH1A 32/4885CYP1A2 465/4885ADH1C 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.