Sugi Predict

Sugi Predict / Compounds / SCHEMBL392987

SCHEMBL392987

SCHEMBL392987

Nc1ccc([N+](=O)[O-])cc1S(N)(=O)=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 7/20 0.57
▸ CA12 O43570 6/20 0.57
▸ CA1 P00915 5/20 0.57
▸ CA9 Q16790 5/20 0.57
▸ CA5A P35218 4/20 0.57
▸ CA14 Q9ULX7 3/20 0.57
▸ CA4 P22748 2/20 0.57
▸ CA6 P23280 2/20 0.57
▸ CA7 P43166 2/20 0.57
▸ CA5B Q9Y2D0 2/20 0.57
▸ CA3 P07451 1/20 0.57
▸ CA13 Q8N1Q1 1/20 0.57
▸ GAA P10253 1/20 0.56
▸ THRB P10828 1/20 0.56
▸ TDP1 Q9NUW8 4/20 0.55
▸ CYP3A4 P08684 4/20 0.53
▸ ALDH1A1 P00352 4/20 0.53
▸ TSHR P16473 1/20 0.52
▸ S1PR4 O95977 1/20 0.51
▸ LMNA P02545 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30451696 1.00 CA2 (0.57) CA2CA12CA1CA9CA5A
SCHEMBL11505093 0.87 CA2 (0.53) CA2CA12CA1CA9CA5A
SCHEMBL18301990 0.83 GAA (0.59) CA2CA12CA1CA9CA5A
SCHEMBL11674536 0.83 TDP1 (0.53) CA2CA12CA1CA9CA5A
SCHEMBL15976059 0.83 TDP1 (0.53) CA2CA12CA1CA9CA5A
SCHEMBL715239 0.83 TDP1 (0.53) CA2CA12CA1CA9CA5A
SCHEMBL67062 0.83 NT5E (0.59) CA2CA12CA1CA9CA5A
SCHEMBL315765 0.83 NT5E (0.59) CA2CA12CA1CA9CA5A
SCHEMBL29696954 0.83 TDP1 (0.53) CA2CA12CA1CA9CA5A
SCHEMBL9440569 0.83 GPR35 (0.56) CA2CA12CA1CA9CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2943468-B1 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER HOFFMANN LA ROCHE (CH) 2017-03-01 — — EP claimed
EP-2943468-A2 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER F.HOFFMANN-LA ROCHE AG (CH) 2015-11-18 — — EP claimed
CN-105051010-A A novel process for the preparation of n-(4-nitro-2-sulfamoyl-phenyl)-malonamic acid methyl ester and n-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester HOFFMANN LA ROCHE 2015-11-11 — — CN claimed
US-8816120-B2 Process for the preparation of N-(4-nitro-2-sulfamoyl-phenyl)-malonamic acid methyl ester and N-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester HOFFMANN-LA ROCHE INC. (US) 2014-08-26 — — US claimed
WO-2014108806-A2 A NOVEL PROCESS FOR THE PREPARATION OF N-(4-NITRO-2-SULFAMOLY-PHENYL)-MALONAMIC ACID METHYL ESTER AND N-(4-AMINO-2-SULFAMOYL-PHENYL)-MALONAMIC ACID METHYL ESTER F. HOFFMANN-LA ROCHE AG (CH) 2014-07-17 — — WO claimed
EP-4053108-B1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-03-11 — — EP disclosed
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF WUHAN LL SCIENCE & TECHNOLOGY DEVELOPMENT CO LTD (CN) 2026-02-26 — — US disclosed
US-12503444-B2 Compound containing benzene ring and application thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2025-12-23 — — US disclosed
CN-119731169-A Sodium channel regulator and application thereof 上海汇伦医药股份有限公司 2025-03-28 — — CN disclosed
CN-115572282-B Pyrazole amide compound containing aromatic heterocyclic structure, and preparation method and application thereof 华东理工大学 2024-07-09 — — CN disclosed
WO-2024046253-A1 SODIUM CHANNEL REGULATOR AND USE THEREOF 上海汇伦医药股份有限公司 2024-03-07 — — WO disclosed
CN-114845996-B Benzene ring-containing compound and application thereof 武汉朗来科技发展有限公司 2023-09-12 — — CN disclosed
US-4134723-A DYEING AROMATIC POLYESTER/POLYAMIDE OR AROMATIC POLYESTER/CELLULOSE BLENDS WITH DISPERSE MONOAZO DYE, ALKALINE BATH IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-01-16 — — US disclosed
US-4118232-A Photographic material containing sulphonic acid group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1978-10-03 — — US disclosed
US-4060544-A COUPLERS GAF CORPORATION (US) 1977-11-29 — — US disclosed
US-4056523-A SULFONAMIDO SUBSTITUTED HOECHST AKTIENGESELLSCHAFT (DT) 1977-11-01 — — US disclosed
US-4051123-A Sulfonic-acid-group containing disazo dyestuffs CIBA-GEIGY AG (CH) 1977-09-27 — — US disclosed
US-4039524-A Keto-amido containing phenylazo benzothiazole dyestuffs GAF CORPORATION (US) 1977-08-02 — — US disclosed
US-3931142-A Heterocyclic containing disazo compounds CIBA-GEIGY AG (CH) 1976-01-06 — — US disclosed
US-3931145-A POLYESTER GAF CORPORATION (US) 1976-01-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260055063-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF CNR2, RYR2, CNR1 CA2 358/4885CA12 1585/4885CA1 116/4885
US-12503444-B2 Compound containing benzene ring and application thereof P2RX4, P2RX7, P2RX2 CA2 403/4885CA12 2530/4885CA1 974/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.