Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44472 | 0.84 | HTT (0.40) | KMT2ATSHRMAPK1HTT | |
| SCHEMBL44314 | 0.82 | HDAC4 (0.42) | ALDH1A1LMNAHTT | |
| SCHEMBL44565 | 0.81 | HPGD (0.51) | ALDH1A1SMN1; SMN2KMT2ATSHRHTT | |
| SCHEMBL45068 | 0.81 | HPGD (0.38) | ALDH1A1KMT2ATSHR | |
| SCHEMBL44623 | 0.81 | FFAR1 (0.42) | ALDH1A1SMN1; SMN2KMT2ATSHRFFAR1 | |
| SCHEMBL44354 | 0.81 | HPGD (0.45) | ALDH1A1SMN1; SMN2KMT2ATSHRHTT | |
| SCHEMBL45433 | 0.80 | GLA (0.37) | ALDH1A1KMT2AFFAR1NPC1RAB9A | |
| SCHEMBL44594 | 0.80 | HTR1A (0.39) | ALDH1A1KMT2ALMNAHTT | |
| SCHEMBL13844940 | 0.80 | MAPT (0.46) | KMT2ATSHRLMNATHRB | |
| SCHEMBL44310 | 0.79 | HPGD (0.50) | ALDH1A1SMN1; SMN2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |