Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930700 | 0.90 | TRPA1 (0.46) | THRBTRPA1ATMGLALMNA | |
| SCHEMBL3932377 | 0.81 | PKM (0.49) | HCRTR1PKMKMT2ALMNATSHR | |
| SCHEMBL3942154 | 0.80 | TRPA1 (0.44) | THRBTRPA1HCRTR2PKMKMT2A | |
| SCHEMBL3933582 | 0.80 | GAA (0.49) | HCRTR1PKMKMT2ALMNATSHR | |
| SCHEMBL3941870 | 0.80 | PKM (0.55) | TRPA1PKMKMT2ALMNATSHR | |
| SCHEMBL14366366 | 0.79 | PKM (0.49) | PKMKMT2ALMNATSHRNPSR1 | |
| SCHEMBL14366808 | 0.73 | POLB (0.46) | PKMKMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3928274 | 0.73 | TRPA1 (0.57) | TRPA1LMNATSHRALDH1A1NPSR1 | |
| SCHEMBL3941453 | 0.72 | BCL9 (0.47) | KMT2ALMNAALDH1A1NPSR1 | |
| SCHEMBL3940272 | 0.72 | ALDH1A1 (0.50) | PKMKMT2ALMNATSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044017-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |