Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL922192 | 0.85 | ANO1 (0.46) | ANO1NLRP3RIPK1NPY5R | |
| SCHEMBL5568675 | 0.78 | NLRP3 (0.44) | ANO1NLRP3NPY5R | |
| SCHEMBL3933572 | 0.78 | ROCK2 (0.49) | — | |
| SCHEMBL4035945 | 0.74 | NR1H2 (0.38) | RIPK1 | |
| SCHEMBL3933114 | 0.74 | NR1H2 (0.36) | — | |
| SCHEMBL3935784 | 0.72 | KMT2A (0.40) | ANO1 | |
| SCHEMBL4035815 | 0.69 | JAK2 (0.55) | NLRP3 | |
| Hydrochloric Acid SCHEMBL921534 | 0.69 | JAK2 (0.54) | NLRP3 | |
| SCHEMBL1228644 | 0.68 | ROCK2 (0.53) | — | |
| SCHEMBL5102413 | 0.65 | GAA (0.66) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |
| EP-1765788-A2 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GmbH (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123688-A2 | 3-AMINOINDAZOLES | MERCK PATENT GMBH (DE) | 2005-12-29 | — | — | WO | disclosed |