Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16104888 | 0.86 | DDB1 (0.35) | ROCK2HDAC4HDAC2HDAC8PPIA | |
| SCHEMBL10768611 | 0.85 | ALDH1A1 (0.39) | ROCK2HDAC4HDAC2HDAC8PPIA | |
| SCHEMBL2318542 | 0.79 | KMT2A (0.38) | PPIAALDH1A1ALOX15LMNAHPGD | |
| SCHEMBL205843 | 0.78 | ROCK2 (0.38) | ROCK2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1315359 | 0.78 | ROCK2 (0.35) | ROCK2ALDH1A1ALOX15LMNAHPGD | |
| SCHEMBL12128642 | 0.77 | TRIM24 (0.39) | PPIAALDH1A1ALOX15LMNAHPGD | |
| SCHEMBL11996804 | 0.77 | MEN1 (0.49) | ALDH1A1ALOX15LMNAHPGDKDM4E | |
| SCHEMBL8963331 | 0.76 | ROCK2 (0.38) | ROCK2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1314189 | 0.75 | ROCK2 (0.33) | ROCK2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL17583591 | 0.74 | ROCK2 (0.33) | ROCK2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409493-B1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | ARLT DIETER (DE) | 2009-04-15 | — | — | EP | disclosed |
| US-6787676-B2 | REACTING A CARBONYL COMPOUND WITH HYDROGEN IN THE PRESENCE OF A CATALYST, A BASE AND OPTIONALLY A DIAMINE, WHERE THE CATALYST IS A SUPPORT-BONDED RUTHENIUM(II) COMPLEX BISPHOSPHINE LIGAND AND A DIAMINE LIGAND | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2004-09-07 | — | — | US | disclosed |
| EP-1409493-A1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | Studiengesellschaft Kohle mbH (DE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2002076997-A1 | METHOD FOR PRODUCING NON-CHIRAL ORGANIC COMPOUNDS CONTAINING OPTICALLY ACTIVE HYDROXY GROUPS | LIGAND CHEMIE GMBH (DE) | 2002-10-03 | — | — | WO | disclosed |
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111515-A1 | Reacting a carbonyl compound with hydrogen in the presence of a catalyst, a base and optionally a diamine, where the catalyst is a support-bonded ruthenium(II) complex bisphosphine ligand and a diamine ligand | PDK1, ADH1A, HRH3 | ROCK2 2062/4885HDAC4 2934/4885HDAC2 1811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.