Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989590 | 0.95 | EPHX1 (0.37) | EPHX1EPHX2POLBLMNASMN1; SMN2 | |
| SCHEMBL3986979 | 0.77 | ALDH1A1 (0.38) | EPHX1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3933529 | 0.75 | CYP2C19 (0.31) | ALDH1A1CYP2C19 | |
| SCHEMBL10321971 | 0.69 | LMNA (0.44) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL10319950 | 0.69 | LMNA (0.44) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL1288426 | 0.69 | LMNA (0.44) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL16439941 | 0.68 | LMNA (0.43) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL4988968 | 0.68 | EPHX1 (0.46) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL14605829 | 0.68 | EPHX1 (0.46) | EPHX1EPHX2LMNASMN1; SMN2KDM4E | |
| SCHEMBL31294147 | 0.68 | EPHX1 (0.46) | EPHX1EPHX2LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046793-A2 | FUSED PYRIMIDO COMPOUNDS | AstraZeneca AB (SE) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008003958-A2 | FUSED PYRIMIDO COMPOUNDS | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |