SCHEMBL3937347

SCHEMBL3937347

O=C(O)NCCC1CCN(CCOc2ccc(Cl)cc2)CC1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 1/20 0.55
HRH3 Q9Y5N1 6/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
ALDH1A1 P00352 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
HTR1A P08908 2/20 0.53
HTR7 P34969 2/20 0.53
KCNA5 P22460 4/20 0.52
CHRM4 P08173 1/20 0.49
FAAH O00519 1/20 0.49
BCHE P06276 1/20 0.49
ACHE P22303 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3946388 0.88 CHRM4 (0.55) HTR1AHTR7CHRM4
SCHEMBL3592177 0.88 FAAH (0.59) SIGMAR1HRH3MEN1KMT2AALDH1A1
SCHEMBL3589202 0.84 FAAH (0.54) SIGMAR1HRH3MEN1KMT2AALDH1A1
SCHEMBL2973774 0.82 FAAH (0.50) SIGMAR1HRH3MEN1KMT2AALDH1A1
SCHEMBL3596798 0.81 HTR1A (0.63) SIGMAR1HRH3MEN1KMT2AALDH1A1
SCHEMBL19692527 0.79 DRD2 (0.58) SIGMAR1HRH3MEN1KMT2AALDH1A1
SCHEMBL19691811 0.78 HRH3 (0.56) SIGMAR1HRH3MEN1KMT2AFAAH
SCHEMBL3938283 0.77 CHRM4 (0.52) SIGMAR1KMT2AHTR7CHRM4
SCHEMBL20610272 0.77 KDM4E (0.59) HRH3MEN1KMT2AALDH1A1L3MBTL1
SCHEMBL9195309 0.76 HTR7 (0.53) HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1720550-B1 DERIVATIVES OF PIPERIDINYLALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI AVENTIS (FR) 2009-04-15 EP claimed
EP-1720550-B1 DERIVATIVES OF PIPERIDINYLALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI AVENTIS (FR) 2009-04-15 EP disclosed
EP-1720550-A1 DERIVATIVES OF PIPERIDINYLALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS Sanofi-Aventis (FR) 2006-11-15 EP disclosed
WO-2005089759-A1 DERIVATIVES OF PIPERIDINYLALKYLCARBAMATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS SANOFI-AVENTIS (FR) 2005-09-29 WO disclosed