Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL394771 | 0.77 | TDP2 (0.42) | MCL1TDP2NSD2HSP90AA1PAX8 | |
| SCHEMBL5734545 | 0.75 | CYP3A4 (0.40) | MAPTCES1ALDH1A1CYP3A4LMNA | |
| SCHEMBL6379555 | 0.74 | CD44 (0.33) | MAPTCYP3A4SMN1; SMN2 | |
| SCHEMBL6681654 | 0.73 | ALDH1A1 (0.48) | MAPTCES1ALDH1A1CYP3A4LMNA | |
| SCHEMBL3239977 | 0.72 | ALDH1A1 (0.39) | MAPTCES1ALDH1A1CYP3A4LMNA | |
| Ammonia Solution, Strong SCHEMBL3875612 | 0.72 | CYP3A4 (0.39) | MAPTCES1ALDH1A1CYP3A4LMNA | |
| SCHEMBL8116564 | 0.71 | CES1 (0.36) | CES1ALDH1A1LMNATDP2NSD2 | |
| SCHEMBL17065148 | 0.70 | CES1 (0.38) | MAPTCES1ALDH1A1MCL1SMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL309539 | 0.70 | ALDH1A1 (0.46) | MAPTCES1ALDH1A1CYP3A4LMNA | |
| SCHEMBL5768842 | 0.68 | POLB (0.56) | MAPTCES1ALDH1A1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044028-A2 | CYANOISOQUINOLINE COMPOUNDS THAT STABILIZE HYPOXIA INDUCIBLE FACTOR (HIF) | FIBROGEN, INC. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007090068-A2 | CYANOISOQUINOLINE COMPOUNDS THAT STABILIZE HYPOXIA INDUCIBLE FACTOR (HIF) | FIBROGEN, INC. (US) | 2007-08-09 | — | — | WO | disclosed |