Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6681654 | 0.82 | ALDH1A1 (0.48) | CES1ALDH1A1MAPTCSNK2A2CSNK2B | |
| SCHEMBL5961683 | 0.81 | CES1 (0.36) | CES1ALDH1A1MAPTSMN1; SMN2CSNK2A2 | |
| Ammonia Solution, Strong SCHEMBL309539 | 0.78 | ALDH1A1 (0.46) | CES1ALDH1A1MAPTCSNK2A2CSNK2B | |
| SCHEMBL2046473 | 0.76 | — | — | |
| SCHEMBL9080722 | 0.74 | KDM4E (0.31) | ALDH1A1MCL1 | |
| SCHEMBL5734545 | 0.71 | CYP3A4 (0.40) | CES1ALDH1A1MAPT | |
| SCHEMBL187040 | 0.71 | TDP2 (0.40) | ALDH1A1SMN1; SMN2MCL1 | |
| SCHEMBL3938147 | 0.70 | MAPT (0.38) | CES1ALDH1A1MAPTSMN1; SMN2CSNK2A2 | |
| Ammonia Solution, Strong SCHEMBL3875612 | 0.69 | CYP3A4 (0.39) | CES1ALDH1A1MAPT | |
| SCHEMBL13038358 | 0.69 | CTRC (0.40) | CES1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544131-B2 | MCL-1 antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190040044-A1 | MCL-1 ANTAGONISTS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2019-02-07 | — | — | US | disclosed |
| US-10040780-B2 | Mcl-1 antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170066747-A1 | MCL-1 ANTAGONISTS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2017-03-09 | — | — | US | disclosed |
| WO-2015134539-A1 | MCL-1 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-09-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544131-B2 | MCL-1 antagonists | MCL1, BAK1, BCL2L1 | CES1 3899/4885ALDH1A1 2157/4885MAPT 4341/4885 |
| US-10040780-B2 | Mcl-1 antagonists | MCL1, BAK1, BCL3 | CES1 4160/4885ALDH1A1 2631/4885MAPT 4316/4885 |
| US-20170066747-A1 | MCL-1 ANTAGONISTS | MCL1, BAK1, BCL3 | CES1 4160/4885ALDH1A1 2631/4885MAPT 4316/4885 |
| US-20190040044-A1 | MCL-1 ANTAGONISTS | MCL1, BAK1, BCL2L1 | CES1 3899/4885ALDH1A1 2157/4885MAPT 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.