Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3939019 | 0.90 | GLS (0.43) | KDM4EALDH1A1PKMMGLL | |
| SCHEMBL3939320 | 0.88 | CYP1A2 (0.39) | KDM4EALDH1A1PKMMEN1KMT2A | |
| SCHEMBL3937537 | 0.80 | ALDH1A1 (0.49) | KDM4EALDH1A1PKMMEN1KMT2A | |
| SCHEMBL3929765 | 0.78 | NPSR1 (0.46) | KDM4EALDH1A1PKMMEN1KMT2A | |
| SCHEMBL3927266 | 0.76 | MCL1 (0.49) | KDM4EALDH1A1PKMMEN1KMT2A | |
| SCHEMBL4842048 | 0.76 | CA5A (0.58) | KDM4EALDH1A1KMT2ANPC1GAA | |
| SCHEMBL2127345 | 0.76 | CYP4F2 (0.43) | ALDH1A1PKMNPC1GAALMNA | |
| SCHEMBL5738807 | 0.76 | CA5A (0.51) | KDM4EALDH1A1KMT2ANPC1GAA | |
| SCHEMBL2126108 | 0.76 | CYP4F2 (0.43) | ALDH1A1PKMNPC1GAA | |
| SCHEMBL30154424 | 0.76 | CYP4F2 (0.43) | ALDH1A1PKMNPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |