Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943715 | 0.86 | ALDH1A1 (0.44) | ALDH1A1KDM4ERGS12MEN1KMT2A | |
| SCHEMBL3937178 | 0.79 | NFE2L2 (0.46) | ALDH1A1MEN1KMT2AMAPTNPC1 | |
| SCHEMBL3944887 | 0.78 | ALDH1A1 (0.45) | ALDH1A1KDM4ERGS12MEN1KMT2A | |
| SCHEMBL3944112 | 0.77 | ALDH1A1 (0.47) | ALDH1A1KDM4ERGS12MEN1KMT2A | |
| SCHEMBL3769364 | 0.76 | L3MBTL1 (0.60) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL3769370 | 0.76 | L3MBTL1 (0.60) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL1399169 | 0.74 | L3MBTL1 (0.61) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL1399170 | 0.74 | L3MBTL1 (0.61) | ALDH1A1KDM4EMAPTNPC1RAB9A | |
| SCHEMBL27524301 | 0.74 | HDAC1 (0.51) | KDM4EMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1399085 | 0.74 | L3MBTL1 (0.60) | ALDH1A1KDM4EMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046748-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | Pierre Fabre Medicament (FR) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007147822-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2007-12-27 | — | — | WO | disclosed |