Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937145 | 0.87 | L3MBTL1 (0.41) | NFE2L2KEAP1CYP3A4CYP2C19MEN1 | |
| SCHEMBL3934665 | 0.85 | KMT2A (0.47) | CYP3A4CYP2C19MAPTALDH1A1KMT2A | |
| SCHEMBL3939893 | 0.79 | ALDH1A1 (0.44) | MAPTMEN1ALDH1A1KMT2AF2R | |
| SCHEMBL3934180 | 0.79 | TDP1 (0.38) | CYP3A4CYP2C19DRD2ALDH1A1KMT2A | |
| SCHEMBL1399075 | 0.78 | MAPT (0.56) | NFE2L2KEAP1CYP3A4CYP2C19DRD2 | |
| SCHEMBL1399078 | 0.78 | MAPT (0.56) | NFE2L2KEAP1CYP3A4CYP2C19DRD2 | |
| SCHEMBL27524301 | 0.76 | HDAC1 (0.51) | MAPTMEN1KMT2APOLBL3MBTL1 | |
| SCHEMBL30443677 | 0.68 | PAM (0.58) | MAPTMEN1ALDH1A1KMT2APOLB | |
| SCHEMBL15540625 | 0.68 | PAM (0.58) | MAPTMEN1ALDH1A1KMT2APOLB | |
| SCHEMBL15540628 | 0.68 | PAM (0.58) | MAPTMEN1ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046748-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | Pierre Fabre Medicament (FR) | 2009-04-15 | — | — | EP | claimed |
| WO-2007147822-A1 | PHENYLPENTADIENOYL DERIVATIVES AND THEIR USE AS PAR 1 ANTAGONISTS | PIERRE FABRE MEDICAMENT (FR) | 2007-12-27 | — | — | WO | claimed |