Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 4/20 | 0.36 |
| ▸ | CASP7 | P55210 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928296 | 0.87 | REN (0.35) | POLBKMT2ARENCASP3CASP7 | |
| SCHEMBL2916072 | 0.85 | MAPT (0.37) | TSHRPOLBTP53RENMAPT | |
| SCHEMBL1036302 | 0.84 | TSHR (0.37) | TSHRPOLBTP53KMT2AREN | |
| SCHEMBL1035254 | 0.83 | TSHR (0.38) | TSHRPOLBTP53KMT2AMAPT | |
| SCHEMBL3935727 | 0.77 | CASP3 (0.39) | POLBKMT2ARENMAPTCASP3 | |
| SCHEMBL3935732 | 0.77 | CASP3 (0.39) | POLBKMT2ARENMAPTCASP3 | |
| SCHEMBL3930174 | 0.77 | FKBP1A (0.42) | TSHRPOLBKMT2AMAPTCASP3 | |
| SCHEMBL2683234 | 0.77 | REN (0.40) | TSHRPOLBTP53KMT2AREN | |
| SCHEMBL3940425 | 0.77 | FKBP1A (0.34) | CASP3CASP7 | |
| SCHEMBL3930886 | 0.77 | CYP2C9 (0.36) | POLBKMT2ARENMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090306062-A1 | 2,5-Disubstituted Piperidines | NOVARTIS AG (CH) | 2009-12-10 | — | — | US | disclosed |
| EP-2044059-A1 | 2,5-DISUBSTITUTED PIPERIDINES | Speedel Experimenta AG (CH) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007141318-A1 | 2,5-DISUBSTITUTED PIPERIDINES | SPEEDEL EXPERIMENTA AG (CH) | 2007-12-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306062-A1 | 2,5-Disubstituted Piperidines | REN, AGTR1, AGTR2 | TSHR 853/4885POLB 2600/4885TP53 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.