Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 2/20 | 0.33 |
| ▸ | METAP1 | P53582 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943243 | 0.82 | FOLH1 (0.39) | ALDH1A1TBXAS1RAB9AFOLH1KDM4E | |
| SCHEMBL4405484 | 0.78 | FOLH1 (0.40) | ALDH1A1TBXAS1RAB9AFOLH1KDM4E | |
| SCHEMBL4405482 | 0.78 | FOLH1 (0.40) | ALDH1A1TBXAS1RAB9AFOLH1KDM4E | |
| SCHEMBL3944732 | 0.78 | METAP2 (0.43) | ALDH1A1L3MBTL1SMN1; SMN2GAAGLA | |
| SCHEMBL23833831 | 0.75 | FOLH1 (0.62) | TBXAS1FOLH1 | |
| SCHEMBL3944750 | 0.73 | TBXAS1 (0.35) | ALDH1A1L3MBTL1TBXAS1SMN1; SMN2HTT | |
| SCHEMBL4016679 | 0.73 | MAPT (0.50) | ALDH1A1SMN1; SMN2FOLH1TDP1 | |
| SCHEMBL3804921 | 0.71 | MAPT (0.54) | ALDH1A1SMN1; SMN2FOLH1TDP1 | |
| SCHEMBL21439803 | 0.71 | MAPT (0.54) | ALDH1A1SMN1; SMN2FOLH1TDP1 | |
| SCHEMBL4015850 | 0.71 | MAPT (0.54) | ALDH1A1SMN1; SMN2FOLH1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507726-B2 | Peptide deformylase inhibitors | SMITHKLINEBEECHAM CORPORATION (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1654239-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20080167302-A1 | Peptide Deformylase Inhibitors | GLAXOSMITHKLINE LLC | 2008-07-10 | — | — | US | disclosed |
| EP-1654239-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005017124-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167302-A1 | Peptide Deformylase Inhibitors | PDF, PEPD, DPEP1 | ALDH1A1 4302/4885L3MBTL1 1474/4885TBXAS1 2302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.