Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 9/20 | 0.43 |
| ▸ | METAP1 | P53582 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944730 | 0.82 | NPC1 (0.43) | HDAC2LTA4HRAB9AMMP1MMP3 | |
| SCHEMBL4392472 | 0.79 | NPC1 (0.43) | HDAC2RAB9A | |
| SCHEMBL4392476 | 0.79 | NPC1 (0.43) | HDAC2RAB9A | |
| SCHEMBL3943247 | 0.78 | ALDH1A1 (0.37) | METAP2METAP1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL3944731 | 0.70 | MAPT (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL20139943 | 0.70 | MAPT (0.45) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL9662596 | 0.70 | CASP1 (0.51) | ALDH1A1KDM4ECASP1KMT2ASMN1; SMN2 | |
| SCHEMBL28557128 | 0.70 | TDP1 (0.46) | ALDH1A1L3MBTL1KDM4ECASP1KMT2A | |
| SCHEMBL13609089 | 0.70 | METAP2 (0.54) | METAP2METAP1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL23833831 | 0.68 | FOLH1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507726-B2 | Peptide deformylase inhibitors | SMITHKLINEBEECHAM CORPORATION (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1654239-A4 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-10-01 | — | — | EP | disclosed |
| US-20080167302-A1 | Peptide Deformylase Inhibitors | GLAXOSMITHKLINE LLC | 2008-07-10 | — | — | US | disclosed |
| EP-1654239-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005017124-A2 | PEPTIDE DEFORMYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167302-A1 | Peptide Deformylase Inhibitors | PDF, PEPD, DPEP1 | METAP2 757/4885METAP1 407/4885ALDH1A1 4302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.