Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942488 | 0.82 | RAB9A (0.49) | POLBHDAC1SMN1; SMN2 | |
| SCHEMBL3943595 | 0.81 | HDAC3 (0.36) | MAPTALDH1A1L3MBTL1HTR2AHTR2C | |
| SCHEMBL3945339 | 0.76 | ALDH1A1 (0.42) | MAPTALDH1A1L3MBTL1HTR2AHDAC1 | |
| SCHEMBL3943591 | 0.75 | RAB9A (0.39) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL4211551 | 0.73 | MAPT (0.59) | MAPTALDH1A1L3MBTL1TP53POLB | |
| SCHEMBL3950434 | 0.73 | ALDH1A1 (0.64) | MAPTALDH1A1L3MBTL1TDP1KDM4E | |
| SCHEMBL3941329 | 0.73 | ALDH1A1 (0.58) | MAPTALDH1A1L3MBTL1KDM4ESMN1; SMN2 | |
| SCHEMBL24999300 | 0.72 | HTR6 (0.45) | HTR2AMTNR1AMTNR1BHDAC3HDAC1 | |
| SCHEMBL3950369 | 0.72 | ALDH1A1 (0.55) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL24746654 | 0.72 | HTR6 (0.49) | MAPTALDH1A1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009019508-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2009-02-12 | — | — | WO | claimed |
| WO-2009019508-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2009-02-12 | — | — | WO | disclosed |