Tomelukast

Tomelukast

SCHEMBL3944

CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 9/20 0.68
CYSLTR1 Q9Y271 9/20 0.68
LMNA P02545 2/20 0.68
MEN1 O00255 1/20 0.68
GLA P06280 1/20 0.68
CYP3A4 P08684 1/20 0.68
ALOX5 P09917 1/20 0.68
ALOX15 P16050 1/20 0.68
TSHR P16473 1/20 0.68
PTGS1 P23219 1/20 0.68
PTGS2 P35354 1/20 0.68
KMT2A Q03164 1/20 0.68
TDP1 Q9NUW8 1/20 0.68
GRM2 Q14416 8/20 0.60
PPARG P37231 2/20 0.55
PPARD Q03181 2/20 0.55
PPARA Q07869 2/20 0.55
CYP1A2 P05177 1/20 0.55
MAPT P10636 1/20 0.55
CYP2C9 P11712 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10693120 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10687830 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10691842 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10694438 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10691896 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL3033071 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10687786 0.99 CYSLTR2 (0.67) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10693436 0.97 CYSLTR2 (0.63) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL9777248 0.91 CYSLTR2 (0.57) CYSLTR2CYSLTR1LMNAMEN1GLA
SCHEMBL10637098 0.88 CYSLTR2 (0.53) CYSLTR2CYSLTR1LMNAMEN1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1931320-B1 MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME FLAMEL IRELAND LTD (IE) 2022-06-15 EP claimed
EP-3400971-B1 ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-08-04 EP claimed
EP-3400969-B1 IMPLANTED DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-05-19 EP claimed
US-10946121-B2 Absorbable iron-based alloy implantable medical device BIOTYX MEDICAL (SHENZHEN) CO., LTD. (CN) 2021-03-16 US claimed
EP-3400970-B1 ABSORBABLE IRON-BASED ALLOY MEDICAL DEVICE IMPLANT LIFETECH SCIENT SHENZHEN CO (CN) 2021-03-03 EP claimed
US-20200215237-A1 ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE BIOTYX MEDICAL (SHENZHEN) CO., LTD. (CN) 2020-07-09 US claimed
US-10570103-B2 Heterocyclic compounds useful in the treatment of disease EPIGEN BIOSCIENCES, INC. (US) 2020-02-25 US claimed
CN-110582305-A Vectors and compositions for the treatment of hemoglobinopathies 蓝鸟生物公司 2019-12-17 CN claimed
US-10377779-B2 Carbonate prodrugs and methods of using the same ACORDA THERAPEUTICS, INC. (US) 2019-08-13 US claimed
US-20190135767-A1 Heterocyclic Compounds Useful In The Treatment Of Disease EPIGEN BIOSCIENCES, INC. (US) 2019-05-09 US claimed
WO-2006044391-A1 A METHOD OF REDUCING DRUG-INDUCED ADVERSE SIDE EFFECTS IN A PATIENT INTERCEPT PHARMACEUTICALS INC. (US) 2006-04-27 WO claimed
US-20060024365-A1 Novel dosage form VAYA NAVIN 2006-02-02 US claimed
US-20060018933-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-20060018934-A1 Novel drug delivery system TORRENT PHARMACEUTICALS LIMITED (IN) 2006-01-26 US claimed
US-6756399-B2 INHIBITORS OF ENZYMES THAT METABOLIZE ARACHIDONIC ACID; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2004-06-29 US claimed
US-20030176421-A1 PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS WATSON JOHN W (US) 2003-09-18 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-0108592-B1 LEUKOTRIENE ANTAGONISTS ELI LILLY AND COMPANY (US) 1987-09-30 EP claimed
US-4661505-A 4-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY) ALKANOIC ACIDS, TETRAZOLES, AND DERIVATIVES ELI LILLY AND COMPANY (US) 1987-04-28 US claimed
EP-0108592-A1 Leukotriene antagonists ELI LILLY AND COMPANY (US) 1984-05-16 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190135767-A1 Heterocyclic Compounds Useful In The Treatment Of Disease LPAR1, LPAR2, LPAR4 CYSLTR2 17/4885CYSLTR1 15/4885LMNA 1097/4885
US-20030176421-A1 PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS OPRM1, OPRK1, OPRD1 CYSLTR2 3991/4885CYSLTR1 4303/4885LMNA 1356/4885
US-10570103-B2 Heterocyclic compounds useful in the treatment of disease LPAR1, LPAR2, LPAR4 CYSLTR2 17/4885CYSLTR1 15/4885LMNA 1097/4885
US-10377779-B2 Carbonate prodrugs and methods of using the same CA6, CA7, CA4 CYSLTR2 3273/4885CYSLTR1 2929/4885LMNA 2401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.