Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3943900 | 0.81 | CASP3 (0.39) | BACE1ALDH1A1RAB9ANPC1CASP3 | |
| SCHEMBL956763 | 0.81 | BACE1 (0.40) | BACE1ALDH1A1KMT2ACASP3 | |
| SCHEMBL3941852 | 0.79 | MTNR1A (0.44) | CASP3TDP1 | |
| SCHEMBL6365366 | 0.72 | ALDH1A1 (0.50) | FFAR1ALDH1A1RAB9AGALR3BRD4 | |
| SCHEMBL12290424 | 0.70 | NPSR1 (0.41) | BACE1ALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL30740885 | 0.70 | FFAR1 (0.62) | FFAR1 | |
| SCHEMBL447652 | 0.70 | FFAR1 (0.62) | FFAR1 | |
| SCHEMBL5642127 | 0.69 | BACE1 (0.42) | FFAR1BACE1P2RX7ALDH1A1TSHR | |
| SCHEMBL9869709 | 0.69 | CASP3 (0.41) | ALDH1A1KMT2ACASP3 | |
| SCHEMBL2410483 | 0.69 | FFAR1 (0.47) | FFAR1ALDH1A1RAB9AGALR3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009020457-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-02-12 | — | — | WO | disclosed |