Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3952586 | 0.90 | ALDH1A1 (0.38) | KEAP1SMN1; SMN2ALDH1A1S1PR5 | |
| SCHEMBL3955855 | 0.90 | PIM1 (0.30) | — | |
| SCHEMBL3957642 | 0.81 | PAOX (0.35) | KEAP1SMN1; SMN2ALDH1A1TLR7S1PR5 | |
| SCHEMBL3944903 | 0.80 | S1PR5 (0.32) | KEAP1SMN1; SMN2ALDH1A1TLR7S1PR5 | |
| SCHEMBL3954983 | 0.80 | KEAP1 (0.32) | KEAP1SMN1; SMN2ALDH1A1S1PR5 | |
| SCHEMBL3947084 | 0.80 | CARM1 (0.41) | — | |
| SCHEMBL3947080 | 0.80 | KEAP1 (0.32) | KEAP1SMN1; SMN2ALDH1A1S1PR5 | |
| SCHEMBL3947071 | 0.79 | DRD2 (0.34) | KEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3949540 | 0.79 | GNAO1 (0.32) | KEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3949506 | 0.78 | ALDH1A1 (0.35) | ALDH1A1S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |