Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 3/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.41 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17611109 | 0.81 | MAOB (0.41) | — | |
| SCHEMBL4023229 | 0.80 | APLNR (0.41) | APLNRAGBL2 | |
| SCHEMBL20470281 | 0.79 | APLNR (0.39) | APLNRJAK2JAK1TYK2JAK3 | |
| SCHEMBL3700412 | 0.79 | APLNR (0.45) | APLNRRAB9ASMN1; SMN2 | |
| SCHEMBL20819365 | 0.75 | ADRB2 (0.52) | APLNR | |
| SCHEMBL31074254 | 0.75 | ADRB2 (0.52) | APLNR | |
| SCHEMBL20819364 | 0.75 | ADRB2 (0.52) | APLNR | |
| SCHEMBL5751931 | 0.75 | BCAT2 (0.51) | BCAT2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20430458 | 0.75 | BCAT2 (0.51) | BCAT2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25171599 | 0.75 | LMNA (0.44) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095712-A2 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009016410-A2 | CHEMICAL COMPOUNDS 831 | ASTRAZENECA AB (SE) | 2009-02-05 | — | — | WO | disclosed |
| WO-2008132502-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |